{"id":4840,"date":"2022-03-28T09:28:26","date_gmt":"2022-03-28T07:28:26","guid":{"rendered":"https:\/\/satdi.umh.es\/?p=4840"},"modified":"2022-03-28T09:28:26","modified_gmt":"2022-03-28T07:28:26","slug":"averiguan-como-una-molecula-marina-se-transforma-en-un-tratamiento-eficaz-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/satdi.umh.es\/ca\/2022\/03\/28\/averiguan-como-una-molecula-marina-se-transforma-en-un-tratamiento-eficaz-contra-el-cancer\/","title":{"rendered":"Esbrinen com una mol\u00e8cula marina es transforma en un tractament efica\u00e7 contra el c\u00e0ncer"},"content":{"rendered":"

Un equip d’investigaci\u00f3 de el Institut Scripps d’Oceanografia<\/a> de la UC Sant Diego<\/a> (els EUA) ha descobert per primera vegada el proc\u00e9s enzim\u00e0tic que activa la mol\u00e8cula salinosporamida A (tamb\u00e9 dita Marizomb), procedent d’un microorganisme mar\u00ed, que actualment es troba en fase III d’assajos cl\u00ednics per al tractament del c\u00e0ncer cerebral.<\/p>\n

L’estudi, publicat en Nature Chemical Biology<\/a>, descriu el proc\u00e9s d’assemblatge del que els investigadors diuen la \u2018ogiva\u2019 anticancer\u00edgena de la salinosporamida A, per part d’un enzim anomenat *SaIC. L’equip va aconseguir desxifrar l’estructura molecular de *SaIC mitjan\u00e7ant un potent accelerador de part\u00edcules que genera llum de raigs X, el Advanced Light Source<\/a>.<\/p>\n

“El nostre estudi resol un enigma de quasi 20 anys sobre com aquest bacteri mar\u00ed fabrica l’ogiva, que \u00e9s exclusiva de la mol\u00e8cula de salinosporamida, i obri la porta a la futura biotecnologia per a fabricar nous agents anticancer\u00edgens.” Katherine Bauman, autora principal d’estudi.<\/p>\n

Segons Bradley Moore, coautor de l’estudi, con\u00e9ixer aquest mecanisme “podria servir en el futur per a utilitzar els enzims en la producci\u00f3 d’altres tipus de salinosporamidas capa\u00e7os d’atacar no sols el c\u00e0ncer, sin\u00f3 tamb\u00e9 malalties del sistema immunitari i infeccions causades per par\u00e0sits.”<\/p>\n

Font: K. Bauman,\u00a0Bradley Moore\u00a0et a<\/em>l\u00a0“Enzymatic assembly of the salinosporamide \u03b3-lactam-\u03b2-lactone anticancer warhead\u201d.\u00a0Nature Chemical Biology<\/em><\/a>\u00a0(marzo, 2022)<\/p>\n

\"Cultivos<\/a>

Cultivos para producir salinosporamida A \/ Erik Jepsen\/ UC San Diego<\/p><\/div><\/p>","protected":false},"excerpt":{"rendered":"

Un equip d’investigaci\u00f3 de el Institut Scripps d’Oceanografia de la UC Sant Diego (els EUA) ha descobert per primera vegada el proc\u00e9s enzim\u00e0tic que activa la mol\u00e8cula salinosporamida A (tamb\u00e9 dita Marizomb), procedent d’un microorganisme mar\u00ed, que actualment es troba en fase III d’assajos cl\u00ednics per al tractament del c\u00e0ncer cerebral.
\nL’estudi, publicat en Nature Chemical […]<\/p>\n","protected":false},"author":4376,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[36688,259,222,633],"tags":[21671,191,913684,283739],"_links":{"self":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts\/4840"}],"collection":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/users\/4376"}],"replies":[{"embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/comments?post=4840"}],"version-history":[{"count":0,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts\/4840\/revisions"}],"wp:attachment":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/media?parent=4840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/categories?post=4840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/tags?post=4840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}