{"id":5546,"date":"2022-10-04T15:38:50","date_gmt":"2022-10-04T13:38:50","guid":{"rendered":"https:\/\/satdi.umh.es\/?p=5546"},"modified":"2022-10-04T15:38:50","modified_gmt":"2022-10-04T13:38:50","slug":"crean-proteinas-a-medida-que-facilitan-el-diseno-de-farmacos-mas-eficaces","status":"publish","type":"post","link":"https:\/\/satdi.umh.es\/ca\/2022\/10\/04\/crean-proteinas-a-medida-que-facilitan-el-diseno-de-farmacos-mas-eficaces\/","title":{"rendered":"Creen prote\u00efnes a mesura que faciliten el disseny de f\u00e0rmacs m\u00e9s efica\u00e7os"},"content":{"rendered":"<p><\/p>\n<p style=\"text-align: justify\">Personal investigador del Consell Superior d&#8217;Investigacions Cient\u00edfiques (CSIC) i del Institute for Protein Design han dissenyat i fabricat noves prote\u00efnes, que no s\u00f3n presents en la naturalesa, amb estructures similars a les immunoglobulines dels anticossos, que s\u00f3n les prote\u00efnes que utilitza el sistema immunitari per a identificar i neutralitzar cossos estranys com a bacteris pat\u00f2gens i virus. Aquesta investigaci\u00f3, publicada en &#8216;Nature Communications&#8217;, permet el disseny de f\u00e0rmacs basats en anticossos monoclonals a mesura, m\u00e9s eficaces, estables i assequibles, les aplicacions de les quals van des del c\u00e0ncer fins a les malalties autoimmunes i les infeccions virals.<\/p>\n<p>Els f\u00e0rmacs basats en anticossos monoclonals consisteixen a modificar una part dels anticossos perqu\u00e8 siguen capa\u00e7os de recon\u00e9ixer dianes terap\u00e8utiques i atacar c\u00e8l\u00b7lules concretes. En paraules de l&#8217;investigador del IBMB-CSIC i co-director de l&#8217;estudi, Enrique Marcos, &#8220;aquest treball descriu una estrat\u00e8gia computacional per a dissenyar xicotetes immunoglobulines (prote\u00efnes) com les dels anticossos amb estructures a mesura, d&#8217;alta estabilitat i amb capacitat per a ancorar zones flexibles amb capacitat d&#8217;uni\u00f3 a la diana buscada&#8221;.<\/p>\n<p>Aquest treball, en el qual tamb\u00e9 han participat equips de la\u00a0Universitat de Toronto, obri la porta al desenvolupament de prote\u00efnes similars als anticossos amb estructures adaptades a diferents necessitats i que presenten millors propietats biof\u00edsiques que els actuals, la qual cosa representaria un gran avan\u00e7 per a la fabricaci\u00f3 de f\u00e0rmacs m\u00e9s accessibles a escala global per al tractament de diferents tipus de c\u00e0ncer, malalties autoimmunes i infeccions virals.<\/p>\n<div id=\"attachment_5549\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/satdi.umh.es\/files\/2022\/10\/imagen-blanco-e1664803413533.png\"><img aria-describedby=\"caption-attachment-5549\" loading=\"lazy\" class=\"wp-image-5549 size-medium\" src=\"https:\/\/satdi.umh.es\/files\/2022\/10\/imagen-blanco-e1664803413533-300x300.png\" alt=\"prote\u00edna\" width=\"300\" height=\"300\" srcset=\"https:\/\/satdi.umh.es\/files\/2022\/10\/imagen-blanco-e1664803413533-300x300.png 300w, https:\/\/satdi.umh.es\/files\/2022\/10\/imagen-blanco-e1664803413533-150x150.png 150w, https:\/\/satdi.umh.es\/files\/2022\/10\/imagen-blanco-e1664803413533.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-5549\" class=\"wp-caption-text\">Model de disseny per a un domini similar a immunoglobulina. IBMB-CSIC<\/p><\/div>\n<p>Font: <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-33004-6\">Nature Communications<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Personal investigador del Consell Superior d&#8217;Investigacions Cient\u00edfiques (CSIC) i del Institute for Protein Design han dissenyat i fabricat noves prote\u00efnes, que no s\u00f3n presents en la naturalesa, amb estructures similars a les immunoglobulines dels anticossos, que s\u00f3n les prote\u00efnes que utilitza el sistema immunitari per a identificar i neutralitzar cossos estranys com a bacteris pat\u00f2gens [&#8230;]<\/p>\n","protected":false},"author":4376,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[36688,259],"tags":[21671,913778,699840],"_links":{"self":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts\/5546"}],"collection":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/users\/4376"}],"replies":[{"embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/comments?post=5546"}],"version-history":[{"count":0,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/posts\/5546\/revisions"}],"wp:attachment":[{"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/media?parent=5546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/categories?post=5546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/satdi.umh.es\/ca\/wp-json\/wp\/v2\/tags?post=5546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}